STUDI SCIENTIFICI

OsteoSpine Terapia eroga un segnale coperto da brevetto, con studi scientifici a supporto della sua efficacia.

Leggi qui gli studi scientifici di riferimento:

 

1. Brighton CT, Wang W, Seldes R, Zhang G, Pollack S.R. Signal transduction in coupled electrical field. J.B.J.S., 2001;83- A 1514 – 1523
2. Aaron RK, Boyan BD, Ciombor D, Schwartz Z, Simon BJ. Stimulation of growth factor synthesis by electric and electromagnetic fields. Clin Orthop 2004;419:30–37
3. Xu J, Wang W, Clark CC, Brighton CT. Signal transduction in electrically stimulated articular chondrocytes involves translocation of extracellular calcium through voltage-gated channels. Osteoarthritis and Cartilage 2009;17:397-405.
4. Brighton CT, Wang W, Clark CC. The effect of electrical fields on gene and protein expression in human osteoarthritic cartilage explants. JBJS Am. 2008;90:833-48.
5. Hartig M, Joos U, Wiesmann HP. Capacitively coupled electric fields accelerate proliferation of osteoblast-like primary cells and increase bone extracellular matrix formation in vitro. Eur Biophys J 2000;29:499-506.
6. Lorich DG, Brighton CT, Gupta R, Corsetti JR, Levine SE, Gelb ID, Seldes R, Pollack SR. Biochemical pathway mediating the response of bone cells to capacitive coupling. Clin Orthop Relat Res 1998;350:246-256.
7. Clark CC, Wang W, Brighton CT. Up-regulation of expression of selected genes in human bone cells with specific capacitively coupled electric fields.J Orthop Res. 2014 Jul;32(7):894-903
8. Wang Z, Clark CC, Brighton CT. Up-regulation of bone morphogenetic proteins in culture murine bone cells with use of specific electric fields. JBJS. 2006;88:1053:1065.
9. Brighton CT, Luessenhop CP, Pollack SR, Steinberg DR, Petrik ME, Kaplan FS. Treatment of castration-induced osteoporosis by a capacitively coupled electrical signal in rat vertebrae. JBJS Am 1989;71:228-236.
10. Gilotra M, Griffith C, Schiavone J, Nimmagadda N, Noveau J, Ludwig SC. Capacitive coupling reduces instrumentation-related infection in rabbit spines: a pilot study. Clin Orthop Relat Res 2012;470:1646-51.
11. Gan JC, Glazer PA. Electrical stimulation therapies for spinal fusion: current concepts. Eur Spine J 2006;15:1301-1311.
12. Oishi M, Onesti ST. Electrical bone graft stimulation for spinal fusion: a review. Neurosurgery 2000; N. 5, Vol. 47.
13. Goodwin CB, Brighton CT, Guyer RD, et al. A double-blind study of capacitively coupled electrical stimulation as an adjunct to lumbar spine fusions. Spine 1999;24:1349-57.
14. Massari L, Brayda-Bruno M, Boriani S, Caruso G, Grava G, Barbanti Brodano G, Cadossi R, Setti S. Effetto della stimolazione biofisica con sistemi capacitivi nel trattamento delle artrodesi vertebrali: studio multicentrico, prospettico, randomizzato ed in doppio cieco. XXXI Congresso Nazionale di Chirurgia Vertebrale G.I.S., Milano 22-24 Maggio 2008.
15. Rossini M, Viapiana O, Gatti D, De Terlizzi F, Adami S. Capacitively coupled electric field for pain relief in patients with vertebral compression fractures and chronic pain. Clin Orthop Relat Res 2010;468:735-740.
16. Piovan E, Rossini M. L’impiego della stimolazione biofisica con tecnica capacitiva nel trattamento dell’edema dell’osso vertebrale. Aitog Oggi Sett/Ott 2013.
17. Sansone V, McCeery J, Longhino V. Post-partum low-back pain of an uncommon origin: a case report. J Back Musculoskel Rehab 2013;26:475-477.
18. Piazzolla A, Solarino G, Bizzoca D, Garofalo N, Dicuonzo F, Setti S, Moretti B. Capacitive coupling electric fields in the treatment of vertebral compression fractures. Journal of Biological Regulators and Homeostatic Agents. 2015; Vol. 29, N. 3:637-646.